Objective To explore the mechanism of Zhilong Huoxue Tongyu capsules in treating oxidative stress injury of cerebral hemorrhage. Methods The total of 45 SD rats were randomly divided into sham operation group （Sham group），intracerebral hemorrhage model group （ICH group），and Zhilong Huoxue Tongyu capsule administration group （ZL group）. ICH group and ZL group were modeld with autologous blood injection method. After successful establishments of the models，ZL group was given Zhilong Huoxue Tongyu capsule （1 g·kg-1·d-1） by gavage，ICH group and ZL group were given an equal dose of normal saline by gavage. After 7 days of feeding，the degrees of neurological impairment in rats in each group were observed，the expression of oxidation factors and antioxidant factors in brain tissue and serum were detected，and the expression of antioxidant stress related proteins in hippocampus tissue were detected. Results Compared with the sham group，the ICH and ZL groups showed more severe neurological deficits，lower levels of antioxidant factors in brain tissue and serum，higher levels of oxidative factors，and higher protein expression of nrf-2-related pathways in brain tissue；Compared with the ICH group，ZL group exhibited a reduced degree of neurological deficit，an increased content of antioxidant factors in brain tissue and serum，a reduced content of oxidative factors，and a higher degree of nrf-2-related pathway protein expression in brain tissue. Conclusion Zhilong Huoxue Tongyu capsules could reduce nerve function injury and brain tissue lesion in rats with cerebral hemorrhage，improve the expression of Nrf-2 related protein，improve the antioxidant capacity of brain tissue，and reduce the oxidative stress injury after cerebral hemorrhage.