Liver is an important digestive and metabolic organ in the human body with strong regenerative potential. Liver failure is a severe liver function decompensation caused by the massive necrosis of liver cells due to multiple reasons，with a high mortality rate，and liver regeneration is the core and key factor in the treatment of liver failure. Liver regeneration is a complex process precisely controlled by multiple factors，while the related mechanisms，liver regeneration indicators that can be used for clinical monitoring，and treatment targets still need to be further improved. Malnutrition is common in patients with liver failure，and malnutrition，including intake and utilization disorders of multiple nutrients，is of great significance for the pathological and physiological processes of liver regeneration. It should be fully valued in the diagnosis and treatment of liver failure，with the aim of promoting liver regeneration through effective nutritional interventions and improving the survival rate of liver failure，especially the non-liver transplantation survival rate.