MA Xinchen, GUO Jinsheng, LIU Liang. Pathogenesis,screening of high-risk population,and the treatment of pancreatic cancer[J]. Journal of Southwest Medical University, 2023,46(2):116-121.
MA Xinchen, GUO Jinsheng, LIU Liang. Pathogenesis,screening of high-risk population,and the treatment of pancreatic cancer[J]. Journal of Southwest Medical University, 2023,46(2):116-121. DOI: 10.3969/j.issn.2096-3351.2023.02.006.
Pancreatic ductal adenocarcinoma(PDAC)is a clinically challenging cancer because it is often diagnosed at an advanced stage and resistant to chemotherapy. However,recent advances in biological research on PDAC have revealed new opportunities for early diagnosis and targeted therapy of PDAC. This article reviewed the progress of pathogenesis of PDAC,including molecular changes in tumor cells,cellular changes in tumor microenvironment,and population-level risk factors. The early detection of PDAC, screening and treatment of high-risk population were also discussed for clincal reference.