Objective A network-based pharmacological approach was used to explore the mechanism and effect characteristics of parasitic loranthus in the treatment of Parkinson's disease （PD）. Methods The main active components and Parkinson's disease-related targets were obtained through literature review，TCMSP，Disgenet and other database screening.The intersection genes were imported into STRING 11.0 database to construct protein interaction （PPI） network model and Cytoscape 3.9.0. The network diagram of "disease-drug-active component-intersection target-KeGG pathway" was constructed by software. GO function and KEGG signaling pathway enrichment of Metascape components in CytoScape were analyzed. Finally，molecular docking was carried out between the screened components and the targets. Results Four main active components，namely quercetin，stigmasterol，anthaldehydes and eugenol，were screened from morifolium，which acted on 27 Parkinson's disease targets，including TNF，IL6，TP53，HMOX1 and IL1B. A total of 708 GO biological processes were involved in the treatment of Parkinson's disease by Mulberry parasite，including inflammatory response，cell oxidation and cell apoptosis.There were 82 KEGG signaling pathways involved，including MAPK，PI3K-Akt and IL-17 signaling pathways. Conclusion Parasitic loranthus showed characteristics of multiple components，multiple targets and multiple pathways in the treatment of Parkinson's disease.