Objective This study was designed to explore the mechanism of Xianqixiaoke Decoction in the treatment of diabetic kidney disease（DKD） by network pharmacology and molecular docking，aiming to provide basis for redevelopment of ancient classical famous formulas. Methods The active ingredients and targets of Xianqixiaoke Decoction were obtained by consulting references and docament retrieval. Genetic chips related to DKD were screened through GEO database and differentially expressed genes（DEGs） were acquired by differential analysis，which were taken as targets associated with DKD. The network maps of drug-components-targets-disease were constructed by Cytoscape software after intersecting the two target data sets. The essential functional modules of PPI core network which was searched by network topology were built by MCODE. The related GO gene function and KEGG pathway enrichment analyses were carried out by applying Bioconductor software. The molecular docking was completed to verify the affinities of active components and key targets. Results A total of 193 active ingredients and 24 targets were obtained. A total of 588 biological processes

47 cell components and 72 molecular functions were obtained by GO analysis from the two modules extracted from the protein interaction core network. A total of 30 pathways were enriched by KEGG analysis. The signal pathways and biological processes closely related to diabetic kidney disease mainly included PI3K-Akt signaling pathway

thyroid hormone signaling pathway

ubiquitin- proteasome system and endoplasmic reticulum stress. Four active ingredients verified by molecular docking，including quercetin，jaranol，DFV and luteolin，played a part in kidney protection. Conclusion Xianqixiaoke decoction played a role in the treatment of diabetic kidney disease through the intervention of multiple components，multiple targets and multiple pathways.