WEN Fuqiang, SHEN Yongchun. Pathogenesis and protective strategies of chronic obstructive pulmonary disease based on mitochondrial dynamics[J]. Journal of Southwest Medical University, 2022,45(5):369-372.
WEN Fuqiang, SHEN Yongchun. Pathogenesis and protective strategies of chronic obstructive pulmonary disease based on mitochondrial dynamics[J]. Journal of Southwest Medical University, 2022,45(5):369-372. DOI: 10.3969/j.issn.2096-3351.2022.05.001.
Chronic obstructive pulmonary disease(COPD)is a chronic airway disease which seriously endangers health. The pathogenesis of COPD is complicated,which brings challenges for its clinical diagnosis and treatment. A growing number of studies sug⁃gest that mitochondrial dynamics play an important role in COPD,and this article aims to introduce the abnormal mitochondrial dynam⁃ics in patients with COPD,the effects of cigarette smoke on mitochondrial dynamics,the role of Mfn2/Opa1/Drp1 in COPD,and poten⁃tial therapeutic strategy based on mitochondrial dynamics,in order to bring new ideas for the prevention and treatment of COPD.