Objective To explore the mechanism of Shenyu Yangxin Capsule in the treatment of cardiac fibrosis. Methods TCMSP，Genecards，String，UniProt，DAVID databases were used for network pharmacology analysis. Topological analysis was carried out with Cytoscape3.72. AutoDock was used for molecular docking. Results 102 ingredients and 161 targets of Shenyu Yangxin capsule were screened out. 3 116 targets of myocardial fibrosis and 43 intersection targets were screened out. 174 and 74 entries were obtained by GO and KEGG enrichment analysis. The important components of Shenyu Yangxin capsules for the treatment of cardiac fibrosis are luteolin，kaempferol β- Sitosterol，tanshinone IIA，ginsenoside Rh2. The important targets were TNF，IL6，IL1B，VEGFA，STAT3. The important biological processes and pathways were TNF signaling pathway，HIF-1 signaling pathway，MAPK signaling pathway，positive regulation of RNA polymerase II promoter transcription，positive regulation of gene expression. The molecular docking results of the key components and key targets showed strong binding ability. Conclusion This study predicted the possible mechanism of Shenyu Yangxin Capsule in the treatment of myocardial fibrosis and provided a theoretical basis for its clinical application.