Objective To explore the application of cell salvage in patients undergoing orthopedic surgeries. Methods Data were retrospectively collected from 63 patients（34 males and 29 females）aged 33 to 66 years who underwent an orthopedic surgery in Ya’ an People’s Hospital from January 2019 to December 2020; all the patients had intraoperative cell salvage; intraoperative blood loss， the volume of intraoperative cell salvage，and the incidence of transfusion-associated adverse reactions 1 to 7 days after surgery were re-corded; comparisons were made for changes in indices such as routine coagulation test results，routine blood test results，blood potassi-um，and blood lactic acid level 1 day after surgery. Results The mean intraoperative blood loss was 621.76 ± 45.34 mL，and the mean volume of cell salvage was 441.37 ± 44.58 mL. There were no obvious transfusion-associated adverse reactions 1 to 7 days after surgery. At 1 day after surgery，the plasma prothrombin time and activated partial thromboplastin time increased，while fibrinogen decreased，but the differences were not significant（P > 0.05）; hematocrit and hemoglobin decreased significantly（P < 0.05）; there were no significant changes in the levels of blood potassium，blood lactic acid，and platelet（P > 0.05）. Conclusion In patients undergoing orthopedic sur-geries，cell salvage has a minor impact on routine blood test results，routine coagulation test results，blood gas，and electrolytes，with no adverse reactions observed.