Gastroesophageal reflux disease（GERD） is a common gastrointestinal disease. GERD can influence patients' health-related quality of life and is associated with an increased risk of esophagitis，esophageal strictures，Barrett esophagus，and esophageal adenocarcinoma. Therefore，the diagnosis and treatment of GERD is very important. The clinical manifestations of GERD are diverse. The accurate diagnosis of GERD often needs to be combined with the symptoms of GERD and the objective results of relat-ed examinations. Different patients with GERD need diverse treatment. This paper focuses on the research progress of diagnosis and treatment of GERD.