Objective To establish a novel antler-based animal model for immediate implant loading， and to investigate the influence of immediate loading on bone remodeling of implants and surrounding bone remodeling. Methods We selected six deer to insert two implants into the left antler of each deer， with one implant loaded immediately and the other unloaded. We harvested the antler specimens with implants of three deer each at 4 and 8 weeks after operation. After micro-CT scanning， morphometric analysis was performed on the antler tissues within 1 mm around the implants. Results As time passed after operation， there were increases in the amount of new bone， bone volume fraction (BV/TV）， trabecular thickness (Tb. Th） and trabecular number (Tb. N）， but a decrease in trabecular separation (Tb. Sp）. The loading group showed higher values of BV/TV， Tb. Th and Tb. N than the unloading group at the same time point. Conclusion This study successfully established a novel regenerative animal model based on antlers for research on immediately loaded implants and surrounding bone remodeling， and confirmed that appropriate immediate loading could promote bone remodeling around implants.