Digestive system diseases are highly diverse and closely associated with human health. In 2021， significant progress and new expert consensus have been made in the study of digestive system diseases. Here， we review the extensively studied areas such as Helicobacter pylori， functional gastrointestinal disease， non-alcoholic fatty liver disease， inflammatory bowel disease and acute pancreatitis. Other research hotspots include gastrointestinal endoscopy and immunotherapy， microbiome，etc.，which also deserve our attention. We hope that this review will provide insights into research in these areas.