Objective To investigate the psychological status of patients with coronavirus disease 2019（CO⁃VID-19）in a designated hospital，and to discuss the coping strategies. Methods The Patient Health Question⁃naire-4（PHQ-4）was used for psychological evaluation for all patients in the inpatient area. Coping strategies were taken based on their psychological issues. Results A total of 82 patients with COVID-19 were surveyed for psycho⁃logical condition. There were 13 cases（15.85%）with a PHQ-4 score of 0~2 points（normal），32（39.02%）with 3~5 points（mild depression），36（43.9%）with 6~8 points（moderate depression），and 1（1.23%）with>9 points （severe depression）. Male and female patients had significant differences in the scores of the following PHQ-4 items: little interest or pleasure in doing things（t=2.889，P=0.004），feeling nervous，anxious，or on edge（t=3.776，P=0.001），not being able to stop or control worrying（t=2.22，P=0.029），and total score（t=3.52，P=0.001）. The univariate analysis of the psychological status of the 82 patients showed that sex was one fac⁃tor affecting the degree of depression（Z=3.803，P＜0.001）. The main reasons influencing patients’psychologi⁃cal state included“I am worried about the prognosis of the disease”（17.5%），“Since there is no specific medicine at present，I don’t think I can get better”（11.2%），“The diet doesn’t suit my taste”（8.8%），and“I am worried about the health of my family”（7.5%）. Conclusion Patients with COVID-19 have varying degrees of depression. Medical staff should provide targeted psychological guidance to help patients overcome the psychological crisis and promote their recovery.