Objective To investigate the clinical features and influencing factors for coronavirus disease 2019（COVID-19）-related liver injury，and to provide a reference for clinical treatment. Methods A total of 68 pa⁃tients with COVID-19 who were admitted to Shandong Provincial Chest Hospital were enrolled，and their clinical features and related influencing factors were analyzed. Results Among the 68 patients with confirmed COVID-19， 56 had mild-or common-type COVID-19（among whom 22 had liver injury）and 12 had severe-or critical-type COVID-19（among whom 11 had liver injury）. Compared with the patients with normal liver function，the patients with liver injury had significantly higher body mass index，lactate dehydrogenase，and α-hydroxybutyrate dehydro⁃genase（P < 0.05）and a significantly lower lymphocyte count（P < 0.05）. The multivariate analysis showed that overweight/obesity（odds ratio [OR]=0.324，95% confidence interval [CI]：0.110~0.956）and severe/critical type （OR=0.085，95% CI：0.010~0.731）were independent risk factors for liver injury. Conclusion Overweight/obe⁃sity and severe/critical type are independent risk factors for COVID-19-related liver injury，and it is necessary to strengthen the measurement，evaluation，and treatment of liver function parameters in patients with overweight/obe⁃sity and severe/critical-type COVID-19.