ObjectiveTo explore the application value of non-invasive left ventricular pressure-strain loop（LV-PSL）in quantitative assessment of myocardial work before and after percutaneous coronary intervention（PCI）in patients with coronary artery disease（CAD）.MethodsThirty CAD patients（case group）who underwent PCI in our hospital and 30 healthy subjects（control group）were prospectively selected.The left ventricular end-diastolic volume（LVEDV）

left ventricular endsystolic volume（LVESV）and left ventricular ejection fraction（LVEF）were calculated by modified biplane Simpson method.The left ventricular global longitudinal strain（GLS）was measured by the two-dimensional speckle tracking echocardiography（2D-STE） myocardial automated functional imaging.The left ventricular global myocardial work index（GWI）

global myocardial constructive work（GCW）

global myocardial wasted work（GWW）and global myocardial work efficiency（GWE）were assessed by non-invasive LV-PSL.The differences of those parameters were compared between the control group and the case group before and 3 d after surgery.And the correlations of GWI

GCW

GWW

GWE with LVEF and GLS were analyzed.ResultsCompared with the control group

the LVEDV

LVESV and GWW of the case group were significantly increased before and 3 d after PCI

and the LVEF

GLS

GWI

GCW and GWE were significantly decreased

and the differences were statistically significant（all P<0.05）.And compared with the case group before PCI

GWW was significantly decreased and GWE was significantly increased 3 d after PCI

and the differences were statistically significant（both P<0.05）

while the LVEDV

LVESV

LVEF

GLS

GWI and GCW had no significant changes.GWI

GCW

GWW

GWE were significantly correlated with LVEF and GLS（all P=0.00）.ConclusionNon-invasive LV-PSL technology can be used to quantitatively evaluate left ventricular myocardial work in CAD patients before and after PCI

and provide a new method to accurately evaluate the effect of CAD on myocardial function and the recovery effect of myocardial function in the short term post-PCI.