Objective To compare the application value of preoperative contrast-enhanced ultrasound（CEUS）and endoscopic ultrasonography（EUS）in clinical staging of bladder cancer.Methods A total of 97 patients with bladder cancer who were admitted to our hospital were selected

they were underwent CEUS and EUS before operation and pathological diagnosis after operation.The results of pathological staging were used as gold standard

the coincidence rate of CEUS and EUS in the clinical staging of bladder cancer was compared.Receiver operating characteristic（ROC）curve was drawn to compare the diagnostic value of two methods for bladder cancer staging.Results Among 97 patients with pathological stage

the number of cases in T1

T2

T3

T4 stage were 27

23

30 and 17

respectively.The coincidence rate of CEUS in T1～T4 stages were 77.78%

86.96%

56.67%

88.24%

respectively.And the coincidence rate of EUS were 74.07%

65.22%

36.67%

17.65%

respectively.There were no significant difference of coincidence rates between the two methods in T1

T2

T3 stages.The coincidence rate of CEUS in T4 stage was higher than that of EUS（P<0.05）.ROC curve analysis showed that the diagnostic sensitivity

specificity

positive predictive value

negative predictive values of CEUS and EUS were 87.50%

82.35%

58.33%

95.89% and 67.50%

64.71%

29.73%

90.00%

respectively

area under curve were 0.849 and 0.661

the difference were statistically significant（all P<0.05）.Conclusion Preoperative CEUS and EUS can be used in the diagnosis of bladder cancer staging

and the diagnostic value of CEUS in patients with T4 stage is higher than that of EUS.