Objective To explore the clinical application value of three-dimensional speckle tracing（3D-STI）and serum indexes in left heart imjury in patients with preeclampsia.Methods A total of 143 pregnant women with preeclampsia admitted to our hospital were selected

they were divided into preeclampsia group（n=82） and combined group（n=61）according to the combination of left cardiac function injury or not.At the same time

normal pregnant women were choosed as control group（n=40）.Conventional ultrasound and 3D-STI were performed on all patients

and serum Ca

+

endothelin（ET）

heart-type fatty acid binding protein（H-FABP）and N-terminal B-type brain natriuretic peptide precursor（NT-proBNP）levels were meascered. The results were compared and analyzed. Pearson analysis was used for correlation analysis among left ventricular ejection fraction（LVEF）

Tei index and 3D-STI parameters and serological indexes.Receiver operating characteristic（ROC）curve was drawn for evaluating the diagnostic efficacy of each index in predicting left heart injury in patient with preeclampsia

and the area under curve（AUC） was calculated.Results There were significant differences of ultrasound parameters including LVEF

Tei index

global longitudinal strain（GLS）

global area strain（GAS）of left ventricular

serological indicators Ca

+

ET

H-FABP and NT-proBNP（all P

<

0.05）.In addition

GLS and GAS in the combined group were significantly lower than those in the preeclampsia group and the control group（all P

<

0.05）.Tei index and GLS in the preeclampsia group were significantly lower than those in the control group（both P

<

0.05）.Ca

+

in the preeclampsia group and the combined group was significantly lower than that in the control group

while ET

H-FABP and NT-proBNP were significantly higher than those in the control group（all P

<

0.05）.ET

H-FABP and NT-proBNP in the combined group were significantly higher than those in the preeclampsia group（all P

<

0.05）. LVEF was positively correlated with GLS

GAS and Ca

+

（all P

<

0.05）

and negatively correlated with ET

H-FABP and NT-proBNP（all P

<

0.05）.Tei index was negatively correlated with GLS

GAS and Ca

+

（all P

<

0.05）

and positively correlated with ET

H-FABP and NT-proBNP（all P

<

0.05）.ROC curve analysis showed that the cutoff values of GLS

ET

H-FABP

NT-proBNP were 15.585%

77.775 μg/L

21.9 μg/L

341.725 μg/L

respectively.The AUC were 0.627

0.643

0.774

0.627

the sensitivity were 0.639

0.885

0.787

0.984

and the specificity were 0.622

0.451

0.634

0.305

respectively.The AUC of combined diagnosis was 0.819

the sensitivity was 0.738 and the specificity was 0.768

and the AUC of combined diagnosis was significantly higher than that of GLS

ET

H-FABP and NT-proBNP alone（all P

<

0.05）.Conclusion The combination of 3D-STI and serological indicators can improve the prediction effect of left heart injury in patients with preeclampsia in clinic

which has higher application value.