Objective To summarize the contrast-enhanced ultrasonic characteristics of pleomorphic adenomas and Warthin tumors of salivary gland.Methods Seventeen patients with pleomorphic adenomas and 16 patients with Warthin tumors underwent contrast-enhanced ultrasound examination and confirmed by surgical histopathology were retrospectively analyzed.Results The contrast-enhanced ultrasonic characteristics of pleomorphic adenomas were mainly synchronal（76.5%）

centripetal（64.7%）

inhomogeneity（76.5%）and hypo-enhancement（70.6%）

with clear boundary after enhancement（88.2%）

visible enhancement rim（94.1%）

and no increase in the mass scope after enhancement（88.2%）.The ultrasonic characteristics of Warthin tumors were fast fill-in（50.0%）

non-centrality（87.5%）

inhomogeneity（62.5%）

and hyper-enhancement（56.3%）.After enhancement

the boundary was clear

the enhancement rim was visible

and the mass scope was not increased（93.8%）.There were statistically significant differences in the enhancement direction and enhancement intensity between pleomorphic adenomas and Warthin tumors（both P<0.05）.The sensitivity

specificity and accuracy were 87.5%

64.7%

75.8% in the diagnosis of Warthin tumor by noncentric enhancement.The sensitivity

specificity and accuracy were 56.3%

100%

78.8% in the diagnosis of Warthin tumor by hyper-enhancement.The sensitivity

specificity and accuracy were 64.7%

87.5%

75.8% in the diagnosis of pleomorphic adenomas by centripetal enhancement.The sensitivity

specificity and accuracy were 70.6%

87.5%and 84.9% in the diagnosis of pleomorphic adenomas by hypo-enhancement.Conclusion The contrast-enhanced ultrasonic characteristics of pleomorphic adenomas and Warthin tumors have certain characteristics

and the enhancement direction and enhancement intensity parameters are helpful to differentially diagnose pleomorphic adenomas and Warthin tumors.