Objective To explore the value of transcranial Doppler（TCD） hemodynamic parameters in predicting intracranial hypertension（ICH） after craniocerebral injury.Methods A total of 122 patients with craniocerebral injury were prospectively enrolled and received TCD monitoring once a day for up to 7 d.The test would be stopped if the patients showed decompensation.According to the presence of ICH

patients were divided into ICH group（n=35） and non-ICH group（n=87）.The peak systolic velocity（Vs）

end diastolic velocity（Vd）

mean velocity（Vm）

pulsatility index（PI）

and resistance index（RI） of middle cerebral artery（MCA） were recorded.The maximum and mean values of each parameter ΔVs

Max

and ΔV

Mean

ΔVd

Max

andΔVd

Mean

△Vm

Max

and △Vm

Mean

ΔRI

Mean

and ΔRI

Max

ΔPI

Mean

and ΔPI

Max

were calculated and compared.The trend of MCA hemodynamic parameters over time was analyzed.COX regression analysis was used to screen independent predictors for the risk of ICH

and the ROC curve was drawn to analyze the diagnostic efficacy in identifying ICH.Results The MCA hemodynamic parameters（Vs

Vm

and Vd） of patients in the non-ICH group showed a downward trend during the monitoring time

while RI and PI showed an upward trend.Compared with the non-ICH group

the ΔPI

Max

value in the ICH group was increased（P=0.014）.COX regression analysis indicated that ΔPI

Max

was an independent predictor of ICH（HR=1.710

P=0.027）.ROC curve analysis indicated that ΔPI

Max

was a good indicator for identifying ICH（AUC=0.904）

cut-off value was 0.148

the sensitivity and specificity were 80.00% and 90.80%

respectively.Conclusion ΔPI

Max

of MCA can accurately identify ICH

and is hope to be used as a new indicator to predict ICH.