ObjectiveTo evaluate the diagnostic value of Kwak TI-RADS and BRAFV600 Egene mutation detection forindeterminate thyroid nodules.MethodsA total of 76 patients with 76 thyroid nodules were selected

which were initiallydiagnosed as indeterminate thyroids nodules

who were underwent ultrasound and BRAFV600 Egene mutation detection. Thereceiver operating characteristic（ROC）curve based on the surgical pathological results or clinical follow-up was drawn

and thediagnostic efficacy of Kwak TI-RADS classification and BRAFV600 Egene mutation detection in differentiating benign andmalignant thyroid nodules with uncertain cytological results was calculated and compared.ResultsSeventy-six cases of thyroidnodules were confirmed by surgical pathology or clinical follow-up

including 50 cases of malignant nodules and 26 cases ofbenign nodules.The sensitivity

specificity

accuracy and area under the curve of BRAFV600 Egene mutation were 62.0%

100%

75.0%

and 0.810

respectively

of which Kwak TI-RADS were 78.0%

76.9%

77.6% and 0.775

respectively

and of whichKwak TI-RADS combined with BRAFV600 Egene mutation detection were 88.0%

84.6%

86.8%

0.873

respectively. Thesensitivity

specificity and accuracy of the combined application of Kwak Ti-RADS and BRAFV600 Egene mutation detection werenot statistically significant compared with the two applications alone.ConclusionFor indeterminate thyroid nodules withindeterminate cytological results

Kwak TI-RADS combined with BRAFV600 Egene mutation detection can certainly improve itsdiagnostic efficacy.