ObjectiveTo investigate the value of contrast-enhanced ultrasound and quantitative analysis in thedifferential diagnosis of delayed phase clearance of hepatitis lesions and hepatocellular carcinoma（HCC）.MethodsThecontrast-enhanced ultrasound data of 38 patients（hepatitis lesion group

with a total of 38 lesions）who were confirmed bysurgery or biopsy and 66 HCC patients（hepatocellular carcinoma group

with a total of 66 lesions）were analyzed.The cut-offvalues of quantitative parameters of contrast-enhanced ultrasound in distinguishing hepatitis lesions from hepatocellularcarcinoma and their diagnostic efficacy were analyzed.ResultsThere were statistically significant differences between thehepatitis lesions group and the hepatocellular carcinoma group in gender

symptoms

serum carbohydrate antigen 125

alpha-fetoprotein（AFP） and hepatitis B virus infection history（all P<0.05）. The proportion of irregular morphology and unclearboundary by contrast-enhanced ultrasound in the hepatitis focus group（23/38

30/38）were higher than those of the hepatocellularcarcinoma group（10/66

4/66）

and the differences were statistically significant（both P<0.01）. There were 30 cases of lowenhancement and 8 cases of isoenhancement in the hepatitis lesion group

26 cases of low enhancement

34 cases ofisoenhancement and 6 cases of high enhancement in the hepatocellular carcinoma group.The difference between the two groupswas statistically significant（all P<0.01）.Quantitative analysis showed that the area under the curve（AUC）of the time-intensity curve of the hepatitis lesion group was larger than that of the HCC group

and the fall time（FT）and mean transit time（MTT）were shorter than those of the HCC group.The differences were statistically significant（all P<0.05）.The results of univariateanalysis showed that taken AUC>365.281

MTT<22 s

FT<35.5 s as cut-off value to distinguish hepatitis lesions fromhepatocellular carcinoma

the sensitivity and specificity were 100% and 68.2%

92.4% and 73.7%

100% and 60.5%

respectively.Logistic regression multivariate analysis showed that the coincidence rate of AUC>365.281 in diagnosing hepatitislesions as benign lesions was 100%.ConclusionContrast-enhanced ultrasound provides important information for thedifferential diagnosis of delayed phase clearance of hepatitis lesions and hepatocellular carcinoma

and quantitative analysis canobjectively show the blood perfusion characteristics of the lesion

which has good clinical application value.