Objective To investigate the effect of automatic breast volume scanner（ABVS）on hormone expressionlevel

and to analyze its evaluation value of neoadjuvant chemotherapy for breast cancer.MethodsA total of 506 breast cancerpatients admitted to our hospital for preoperative neoadjuvant chemotherapy were selected for ABVS examination before and afterchemotherapy

the size of breast mass was measured

the signs of ABVS were recorded

and the expressions of ER

PR and HER-2 were detected by postoperative immunohistochemistry.According to the efficacy of chemotherapy

patients were divided into theeffective group and the non-effective group

and the differences in the size of breast mass between the two groups before and afterchemotherapy

as well as the differences in the signs of ABVS in patients with different ER

PR and HER-2 expression levelswere compared.ResultsAmong the 506 patients

498 patients finally completed neoadjuvant chemotherapy

including 365 patients in the effective group and 133 patients in the ineffective group.The length

width

thickness

area and volume of breastmass of 498 patients after neoadjuvant chemotherapy were reduced compared with those before chemotherapy

and thedifferences were statistically significan（tall P<0.05）.The length

width

thickness

area and volume of breast mass in the effectivegroup were reduced compared with those in the ineffective group

and the differences were statistically significant（all P<0.05）.The detection rates of"burr sign"and"aggregation sign"in patients with positive ER and PR expressions were higher than thosewith negative ER and PR expressions（χ2"burr sign"=10.367

13.540

χ2"aggregation sign"=28.050

30.710

all P<0.05）.The detection rate ofcalcification in patients with positive HER-2 expression was higher than that in patients with negative HER-2 expression（χ2=26.646

P<0.05）.ConclusionThe hormone expression level has a certain effect on the ABVS image characteristics.ABVS canaccurately evaluate the effect of neoadjuvant chemotherapy for breast cancer and has good clinical application value.