ObjectiveTo explore the application value of gray-level ratio in the differential diagnosis of benign andmalignant breast lesions.MethodsA total of 328 patients with 337 lesions confirmed by breast biopsy in our hospital wereselected

including 184 benign cases and 154 malignant lesions. The gray-level ratio of benign and malignant lesion tosurrounding tissue was calculated by the histogram of the Adobe Photoshop software

and the difference was compared. Thediagnostic efficiency of gray-level ratio in predicting malignant lesions was analyzed by the receiver operating characteristic（ROC）curve.ResultsThe gray-level ratio of benign and malignant lesions to surrounding normal tissues were 0.47±0.18 and0.30 ± 0.16

respectively

and the difference was statistically significant（P<0.05）. When the gray-level ratio was 0.335

thesensitivity

specificity and area under the curve in the differential diagnosis of benign and malignant lesions were 77.6%

63.6%and 0.777

respectively.ConclusionGray-level ratio has a certain value in the differential diagnosis of benign and malignantbreast lesions.