ObjectiveTo investigate the application value of acoustic radiation force impulse imaging（ARFI）combined with stress elastography in the diagnosis of hysteromyoma degeneration.MethodsA total of 115 lesions were selected from 98 patients with hysteromyoma degeneration confirmed by surgical pathological results in our hospital

including 22 lesions in degeneration group and 93 lesions in undenatured group. Conventional ultrasound was used to observe the size

location

blood flow and internal echo of the lesion. Stress elastography was used to observe the lesion elasticity score. ARFI was used to measured shear wave velocity（VTQ）. The differences of above parameters were compared between the two groups. The receiver operating characteristic（ROC）curve was drawn to analyze and compare the efficacy of ARFI

stress elastography and combined diagnosis.ResultsThere were no significant difference of location

blood flow and internal echo of hysteromyoma between degeneration group and undenatured group. The patients in two groups with a diameter ≥5 cm or <5 cm were statistically different（P<0.05）. The elastic score and VTQ in degeneration group were lower than those in undenatured group

and the differences were statistically significant（both P<0.05）. The area under the ROC curve of ARFI for judging hystero myoma degeneration was 0.71

the sensitivity

specificity and accuracy were 65.52%

79.10% and 88.69%

respectively

when VTQcutoff value was 2.52 m/s. The sensitivity

specificity and accuracy of stress elastography for judging hysteromyoma degeneration were 63.63%

93.55% and 87.83%

respectively. The sensitivity

specificity and accuracy of ARFI combined with stress elastography for assessing of hysteromyoma degeneration were 86.36%

95.59% and 90.43%

respectively. Compared with the single technique

the difference of diagnostic efficacy was statistically significant（all P<0.05）.ConclusionARFI combined with stress elastography can significantly improve the differential diagnostic value in the diagnosis of hysteromyoma degeneration or not.