Objective To investigate the clinical application value of virtual touch tissue imaging quantification（VTIQ） technique in detecting acute liver failure（ALF）and evaluating the effect of preventive medication in rats.Methods Twenty-four male SD rats were randomly divided into the control group

the model group and the treatment group with eight rats in each group. The treatment group was treated by gavage with Medilac-S(100 mg·kg

-1

·d

-1

)after dilution

while the control group and the model group were treated with the same volume of warm normal saline for 8 d. On the 6 th and 7 th day of the experiment

the model group and the treatment group were intraperitoneally injected with TAA(200 mg·kg

-1

·d

-1

). The shear wave velocity（SWV）of liver were measured and compared among three groups before and after the establishment of the model.Taken pathological result as the golden standard

ROC curve was drawn to obtain the cut-off value for predicting ALF by SWV

and area under the curve was calculated.Results Before modeling

the SWV mean of control group

model group and treatment group were（2.43 ± 0.57）m/s

（2.61 ± 0.42）m/s and（2.71 ± 0.49）m/s

respectively

and the difference was not statistical significance. After modeling

the SWV mean of control group

model group and treatment group were（2.50±0.71）m/s

（3.56±0.48）m/s and（3.06±0.27）m/s

respectively. The SWV mean in the model group was higher than that in the control group

and the difference was statistical significance（P

<

0.05）. With cut-off value of 2.83 m/s

the area under the curve

sensitivity and specificity were 0.938

100% and 75.00% in predicting ALF

respectively.Conclusion The VTIQ technique has a potential application value in predicting ALF and evaluating the effect of preventive medication.