Objective To investigate the hemodynamic changes of patients with refractory hyperthyroidism and its correlation with related serological indicators.Methods One hundred and fifty-six patients with refractory hyperthyroidism（hyperthyroidism group）and 121 healthy individuals as the control group were enrolled.All the selected subjects were underwent ultrasonography and laboratory examination. Various indexes were compared between two groups

including hemodynamic parameters

serological indicators total triiodothyronine（TT3）

total thyroxine（TT4）

free triiodothyronine（FT3）

free thyroxine（FT4）

and thyroid stimulating hormone（TSH）.The correlation between hemodynamic parameters and serological parameters was analyzed by Pearson correlation analysis.Results The thyroid volume

maximum blood flow velocity and tube diameter of the hyperthyroidism group were significantly higher than those of the control group（all P<0.05）.The blood flow resistance index of the hyperthyroidism group was higher than that of the control group

with no significant difference.The levels of serum TT3

TT4

FT3 and FT4 of the hyperthyroidism group were significantly higher than those of the control group（all P<0.05）

and TSH level was lower than that of the control group（P<0.05）. Pearson correlation analysis showed that TSH level were negatively correlated with thyroid volume

maximum blood flow velocity

and tube diameter（all P<0.05）

while TT3

TT4

FT3 and FT4 were positively correlated with thyroid volume

maximum blood flow velocity and tube diameter（all P<0.05）.Conclusion The thyroid volume

maximum blood flow velocity and tube diameter of patients with refractory hyperthyroidism are correlated with serological indicators

which can reflect the severity of refractory hyperthyroidism

thus providing reliable reference for diagnosis

treatment and monitoring of refractory hyperthyroidism.