Objective To investigate the correlation between ultrasound vascularization index（VI） and tumormarkers and angiogenesis indexes in patients with thyroid cancer.Methods Sixty cases of thyroid cancer patients and 60 casesof thyroid adenoma patients in our hospital were selected as thyroid cancer group and thyroid adenoma group.All patients wereexamined by three-dimensional power Doppler ultrasound

and VI was obtained.The levels of tumor markers and angiogenesis

such as serum thyroglobulin（TG）

carcinoembryonic antigen（CEA）

galactose hemagglutinin-3（Gal-3）

vascular endothelialgrowth factor（VEGF）

angiopoietin-2（Ang-2） and insulin-like growth factor-Ⅱ（IGF-Ⅱ） were obtained by laboratoryexamination.The differences of above laboratory examination indexes and VI were compared between the two groups and differenttypes of thyroid cancer patients. The correlation between VI and tumor markers and angiogenesis indexes were analyzed byPearson correlation analysis.Results The VI

TG

CEA

Gal-3

VEGF

Ang-2 and IGF-Ⅱ of thyroid cancer group were higherthan those of thyroid adenoma group（all P<0.05）.The VI of patients with TNM stage Ⅲ～Ⅳ was higher than that of patients withstage Ⅰ～Ⅱ

and that of patients with lymph node metastasis was higher than that of patients without metastasis（both P<0.05）.The Pearson correlation analysis showed that the VI of thyroid cancer patients was positively correlated with the level of TG

CEA

Gal-3

VEGF

Ang-2 and IGF-Ⅱ（all P<0.05）.Conclusion The VI of patients with thyroid cancer is significantlyincreased

and it is positively related to the tumor markers and angiogenesis indexes.It can be used as an important referenceindex for clinical diagnosis and evaluation of patients with thyroid cancer.