超声造影引导下单极射频消融与无接触多极射频消融治疗肝肿瘤的对比研究

陈萍; 唐春霖; 陈凯旋; 谭鹰; 马宽生; 夏锋; 冯凯; 柴跃龙; 郭燕丽

doi:10.16245/j.cnki.issn1008-6978.2020.09.002

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超声造影引导下单极射频消融与无接触多极射频消融治疗肝肿瘤的对比研究

临床研究 | 更新时间：2021-10-08

- 超声造影引导下单极射频消融与无接触多极射频消融治疗肝肿瘤的对比研究
- Comparative study of monopolar radiofrequency ablation and no-touch multipolar radiofrequency ablation in the treatment of liver tumors under the guidance of contrast-enhanced ultrasound
- 临床超声医学杂志 2020年22卷第9期页码：647-650
- 作者机构：
  
  1. 陆军军医大学第一附属医院超声科
  2. 陆军军医大学第一附属医院肝胆科
- 作者简介：
- 基金信息：
  
  国家国际科技合作专项项目（2015DFA30920）;重庆市科技研发基地建设计划（国际科技合作）项目（cstc2014gjhz110004）
- DOI：10.16245/j.cnki.issn1008-6978.2020.09.002
  中图分类号： R735.7;R445.1
- 纸质出版日期：2020，
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[1]陈萍,唐春霖,陈凯旋,谭鹰,马宽生,夏锋,冯凯,柴跃龙,郭燕丽.超声造影引导下单极射频消融与无接触多极射频消融治疗肝肿瘤的对比研究[J].临床超声医学杂志,2020,22(09):647-650.

CHEN Ping, TANG Chunlin, CHEN Kaixuan, et al. Comparative study of monopolar radiofrequency ablation and no-touch multipolar radiofrequency ablation in the treatment of liver tumors under the guidance of contrast-enhanced ultrasound[J]. Journal of Clinical Ultrasound in Medicine, 2020,22(9):647-650.
[1]陈萍,唐春霖,陈凯旋,谭鹰,马宽生,夏锋,冯凯,柴跃龙,郭燕丽.超声造影引导下单极射频消融与无接触多极射频消融治疗肝肿瘤的对比研究[J].临床超声医学杂志,2020,22(09):647-650. DOI： 10.16245/j.cnki.issn1008-6978.2020.09.002.

CHEN Ping, TANG Chunlin, CHEN Kaixuan, et al. Comparative study of monopolar radiofrequency ablation and no-touch multipolar radiofrequency ablation in the treatment of liver tumors under the guidance of contrast-enhanced ultrasound[J]. Journal of Clinical Ultrasound in Medicine, 2020,22(9):647-650. DOI： 10.16245/j.cnki.issn1008-6978.2020.09.002.

摘要

目的对比分析超声造影引导下单极射频消融（M-RFA）与无接触多极射频消融（No-touch RFA）治疗肝肿瘤的临床应用价值。方法回顾性分析在我院行超声造影引导下M-RFA和No-touch RFA治疗肝肿瘤的94例患者（M-RFA组44例

No-touch RFA组50例）的检查资料

比较两组患者术后病灶灭活范围和灭活率

以及治疗前后实验室检查指标的差异;随访24个月

观察患者的无瘤生存率。结果射频消融后

超声造影测量M-RFA组肿瘤灭活范围平均值为38.36 mm×31.31 mm

No-touch RFA组为46.70 mm×35.82 mm;M-RFA组完全灭活率为90.9%（40/44）

No-touchRFA组为98.00%（49/50）

差异有统计学意义（P<0.05）。M-RFA组21例患者甲胎蛋白阳性

RFA术后1个月9例明显下降

12例转阴;No-touch RFA组20例患者甲胎蛋白阳性

RFA术后1个月6例明显下降

14例转阴

两组术前术后比较差异均有统计学意义（均P<0.001）。术后随访24个月

M-RFA组无瘤生存率为47.72%（21/44）

No-touch RFA组为68.00%（34/50）

差异有统计学意义（P=0.041）。结论超声造影引导下No-touch RFA治疗肝肿瘤有助于提高肿瘤的灭活率

疗效显著

无瘤生存率高

较M-RFA临床应用价值更佳。

Abstract

Objective To investigate the clinical value of contrast-enhanced ultrasound（CEUS）guided monopolarradiofrequency ablation（M-RFA）and no-touch multipole radiofrequency ablation（No-touch RFA）in the treatment of livertumors.Methods A total of 94 cases of liver tumors patients treated with M-RFA and No-touch RFA under the guidance ofreal-time CEUS in our hospital were enrolled

including 44 cases of M-RFA group and 50 cases of No-touch RFA group.Thepostoperative lesion inactivation range

inactivation rate and lab examination indexes before and after treatment were compared.The patients were followed up regularly for 24 months and the tumor-free survival rate was recorded.Results After treatment

the average inactivation range of the M-RFA group and the No-touch RFA group by CEUS were 38.36 mm×31.31 mm and46.70 mm×35.82 mm

respectively.The total inactivation rate of the M-RFA group and the No-touch RFA group were 90.9%（40/44）and 98.00%（49/50）

respectively.The difference was statistically significant（P<0.05）.After treatment

21 AFP positivepatients in the M-RFA group

12 cases were transferred into negative AFP and serum AFP level in 9 cases decreasedsignificantly 1 month after treatment. 20 AFP positive patients in the No-touch RFA group

14 cases were transferred intonegative AFP and serum AFP level in 6 cases decreased significantly 1 month after treatment.The difference of preoperative andpostoperative AFP levels between the two groups were statistically significant（both P<0.05）.Regular follow-up to 24 months after treatment showed that the tumor-free survival rate was 47.72%（21/44）in the M-RFA group and 68.00%（34/50）in theNo-touch RFA group

and the difference was statistically significant（P=0.041）.Conclusion CEUS guided No-touch RFAtreatment of liver tumors is helpful to improve the tumor inactivation rate with significant efficacy and high tumor-free survivalrate

which has better application value than M-RFA.

关键词

超声检查造影剂射频消融单极多极肝肿瘤

Keywords

UltrasonographyContrast agentRadiofrequency ablationMonopolarMultipolarLiver tumors

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