甲状腺乳头状癌伴桥本甲状腺炎的超声表现及其与侵袭性和BRAF<sup>V600E</sup>突变的关系

陈妮; 黄晓玲; 刘丽萍; 李茂萍; 彭晓琼

doi:10.16245/j.cnki.issn1008-6978.2020.07.013

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甲状腺乳头状癌伴桥本甲状腺炎的超声表现及其与侵袭性和BRAF^V600E突变的关系

临床研究 | 更新时间：2021-10-08

- 甲状腺乳头状癌伴桥本甲状腺炎的超声表现及其与侵袭性和BRAF^V600E突变的关系
- Relationship between ultrasonographic features of papillary thyroid carcinoma with Hashimoto’s thyroiditis and its invasiveness and BRAF^V600E mutations
- 临床超声医学杂志 2020年22卷第7期页码：515-518
- 作者机构：
  
  重庆医科大学附属第一医院超声科
- 作者简介：
- 基金信息：
- DOI：10.16245/j.cnki.issn1008-6978.2020.07.013
  中图分类号： R736.1;R445.1;R581.4
- 纸质出版日期：2020，
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[1]陈妮,黄晓玲,刘丽萍,李茂萍,彭晓琼.甲状腺乳头状癌伴桥本甲状腺炎的超声表现及其与侵袭性和BRAF~(V600E)突变的关系[J].临床超声医学杂志,2020,22(07):515-518.

CHEN Ni, HUANG Xiaoling, LIU Liping, et al. Relationship between ultrasonographic features of papillary thyroid carcinoma with Hashimoto’s thyroiditis and its invasiveness and BRAF^V600E mutations[J]. Journal of Clinical Ultrasound in Medicine, 2020,22(7):515-518.
[1]陈妮,黄晓玲,刘丽萍,李茂萍,彭晓琼.甲状腺乳头状癌伴桥本甲状腺炎的超声表现及其与侵袭性和BRAF~(V600E)突变的关系[J].临床超声医学杂志,2020,22(07):515-518. DOI： 10.16245/j.cnki.issn1008-6978.2020.07.013.

CHEN Ni, HUANG Xiaoling, LIU Liping, et al. Relationship between ultrasonographic features of papillary thyroid carcinoma with Hashimoto’s thyroiditis and its invasiveness and BRAF^V600E mutations[J]. Journal of Clinical Ultrasound in Medicine, 2020,22(7):515-518. DOI： 10.16245/j.cnki.issn1008-6978.2020.07.013.

摘要

目的探讨桥本甲状腺炎（HT）是否会影响甲状腺乳头状癌（PTC）的常规超声特征表现

及其与侵袭性和BRAF

V600E

突变的关系。方法将158例经手术证实的PTC患者分为HT组和非HT组

每组各79例

比较两组常规超声、超声造影及弹性成像特征

以及侵袭性和BRAF

V600E

突变的差异性。应用二元Logistic回归分析超声特征与BRAF

V600E

基因突变的相关性。结果 HT组中女性患者比例高于非HT组

差异有统计学意义（P

0.05）。两组超声特征（病灶边界、纵横比、微小癌、微钙化、病灶数目、颈部淋巴结转移）、超声造影增强模式、弹性成像评分比较差异均无统计学意义。158例患者中

18例侵袭周围组织

其中HT组5例

非HT组13例;135例BRAF

V600E

突变阳性

其中HT组63例

非HT组72例

差异均有统计学意义（均P

0.05）。135例BRAF

V600E

突变阳性病例中

两组淋巴结转移比较差异无统计学意义;侵袭周围组织情况比较差异有统计学意义（P

0.05）。二元Logistic回归分析显示

158例PTC患者中

微小癌和纵横比

1与BRAF

V600E

突变阳性相关（OR=3.087、3.798

均P

0.05）;HT组患者中

微小癌与BRAF

V600E

突变阳性相关（OR=3.590

0.05）。结论 PTC合并HT好发于女性

HT不影响PTC的超声特征表现

合并HT的PTC其侵袭性及BRAF

V600E

基因突变率均低于单纯的PTC;在PTC中

BRAF

V600E

基因突变与微小病灶、纵横比

1均相关;合并HT的PTC中BRAF

V600E

基因突变与微小病灶相关。

Abstract

Objective To investigate whether Hashimoto’s thyroiditis affects the sonographic features of papillary thyroid carcinoma（PTC） and its relationship with its invasiveness and BRAF

V600E

mutations.Methods A total of 158

tients with positive PTC were divided into HT group and non-HT group（79 cases in each group）.The features of conventional ultrasound and contrast-enhanced ultrasound

elastography

invasiveness and BRAF

V600E

mutations were compared between the two groups.Binary Logistic regression was used to analyze the correlation between ultrasound features and BRAF

V600E

mutations.Results The proportion of female patients in HT group was higher than that in non-HT group（P

0.05）.There were no significant differences between the two groups in ultrasonic features（boundary of lesion

aspect ratio

microcarcinoma

microcalcification

number of lesion

cervical lymph node metastasis）

contrast-enhanced ultrasound mode and elastography scores.Among 158 cases

18 cases invaded the surrounding tissues

5 cases in HT group and 13 cases in non-HT group.135 cases were BRAF

V600E

mutations positive

63 cases in HT group and 72 cases in non-HT group

the differences were statistically significant（all P

0.05）.In 135 BRAF

V600E

mutations positive cases

there was no significant difference in lymph node metastasis between the two groups

but there was significant difference in invasion（P

0.05）.In 158

tients with PTC

BRAF

V60 E

mutations was positively correlated with microcarcinoma and aspect ratio

1（OR=3.087

3.798

both P

0.05）

and BRAF

V600E

mutations was positively correlated with microcarcinoma in HT group（OR=3.590

0.05）.Conclusions PTC with HT is more common in women.The presence of HT can not affect the sonographic features of PTC

the invasiveness of PTC with HT and the mutation rate of BRAF

V600E

gene are lower than that of PTC.In PTC

the mutations of BRAF

V600E

is related to microfocus

aspect ratio

1.Mutations of BRAF

V600E

gene in PTC with HT are associated with microlesions.

关键词

超声成像甲状腺乳头状癌桥本甲状腺炎BRAFV600E

Keywords

Ultrasound imagingPapillary thyroid carcinomaHashimoto’s thyroiditisBRAFV600E

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甲状腺乳头状癌伴桥本甲状腺炎的超声表现及其与侵袭性和BRAFV600E突变的关系

Relationship between ultrasonographic features of papillary thyroid carcinoma with Hashimoto’s thyroiditis and its invasiveness and BRAFV600E mutations

DOI：10.16245/j.cnki.issn1008-6978.2020.07.013

摘要

Abstract

关键词

Keywords

references

甲状腺乳头状癌伴桥本甲状腺炎的超声表现及其与侵袭性和BRAF^V600E突变的关系

Relationship between ultrasonographic features of papillary thyroid carcinoma with Hashimoto’s thyroiditis and its invasiveness and BRAF^V600E mutations