ObjectiveTo evaluate the ophthalmic artery hemodynamic changes induced by safflower injectioniontophoresed through ocular skin by color Doppler ultrasound.MethodsForty healthy subjects（80 eyes）in our hospital wereinvolved in this reseach. The right eyes were covered with a veil soaked with 20 ml safflower injection（treatment group）

the lefteyes were covered with a veil soaked with 20 ml normal saline（control group）. The two groups were treated with iontophoresis atthe same time for 20 min. The changes of the PSV

EDV and RI of CRA

PCA and OA in two groups were detected by colorDoppler ultrasound and comparative analysis were made.ResultsAfter safflower injection was applied through ocular skiniontophoresis

the PSV and EDV of CRA

PCA and OA of the right eyes were（14.93±2.36）cm/s and（4.81±1.03）cm/s

（14.74±2.64）cm/s and（5.36±1.10）cm/s

（35.91±6.71）cm/s and（8.13±2.36）cm/s

PSV-EDV was increased

there were significantlydifferences before and after safflower injection iontophoresis（all P<0.05）.There was no significant difference of resistanc indexbetween the two groups. For the left eyes

there was no significant hemodynamic changes before and after the treatment.ConclusionSafflower injection through ocular skin iontophoresis leads to significant changes in ophthalmic arteryhemodynamics.The color Doppler ultrasound could provide the quantitative evaluation information for the treatment of safflowerinjection through ocular skin iontophoresis.