ObjectiveTo explore the diagnostic value of qualitative and quantitative parameters of contrast-enhanced ultrasonography（CEUS）in differentiating benign and malignant breast nodules.MethodsTwo hundred and thirty-three cases of breast nodules confirmed by ultrasound-guided biopsy or pathology after operation were selected

including 95 cases of malignant nodules and 138 cases of benign nodules.The qualitative and quantitative parameters of CEUS in the breast lesions were observed

and univariate analysis was carried out. Statistically significant qualitative and quantitative parameters were screened for binary Logistic regression analysis

and receiver operating characteristic（ROC）curve was obtained to evaluate the efficacy of the parameters in the diagnosis of malignant nodules.Results Univariate analysis showed that CEUS enhancement intensity

enhancement speed

morphology

enhancement range

enhancement boundary

marginal burr

perfusion defect and peak intensity（Peak%）were statistically significant difference for the diagnosis of benign malignant breast nodules（all P<0.05）.Logistic regression analysis showed that the optimized diagnostic indexes and parameters were the enhanced range

perfusion defect

marginal burrs

the enhanced boundary and the enhanced morphology（all P<0.05）.The accuracy of Logistic regression model in predicting malignant breast nodules was 81.5%

the area under the ROC curve was 0.894

the sensitivity and specificity were 0.811 and 0.841

respectively.ConclusionThe CEUS features of breast

such as enlarged area

perfusion defect

marginal burr

unclear border and irregular shape are helpful to diagnose malignant breast nodules.