ObjectiveTo systematically review the value of contrast-enhanced ultrasound in the detection of activeCrohn’s disease.MethodsLiteratures that evaluated the diagnostic potency of contrast-enhanced ultrasound in Crohn’sdisease from establishment to January 2020 were searched in databases including Pub Med

Embase

The Cochrane Library

CNKI

Wan Fang and VIP.Two researchers screened the literature

extracted the data

and evaluated the risk of bias of includedstudies based on the QUADAS-2 tool.The Meta-analysis was performed using Meta Disc 1.4 and Stata 12.0 software.ResultsAtotal of 16 articles were included

involving 18 studies. The results of Meta-analysis showed that the pooled sensitivity

specificity

positive likelihood ratio

negative likelihood ratio and diagnostic odds ratio of contrast-enhanced ultrasound in thediagnosis of active Crohn’s disease were 0.94（0.92～0.96）

0.76（0.71～0.81）

3.30（2.60～4.10）

0.07（0.03～0.18）

64.72（27.87～150.28）

respectively.The area under the curve was 0.92.Subgroup analysis showed that the enhanced curve had the highestdiagnostic value（area under the curve was 0.95）

while the presence enhancement

enhancement patterns

and relativeenhancement were less useful（area under the curve were 0.92

0.93

0.85

respectively）.ConclusionContrast-enhancedultrasound has definite diagnostic value in the detection of active Crohn’s disease

especially under the condition of using theenhanced curve parameter as the threshold.