ObjectiveTo explore the value of contrast-enhanced ultrasound（CEUS）in the differential diagnosis ofbenign and malignant testicular lesions.MethodsThe CEUS characteristics of 81 cases of testicular lesions confirmed bysurgical pathology in our hospital were analyzed retrospectively. Six CEUS characteristics of the benign and malignant testicularlesions were analyzed.The six characteristics were as follows:the boundary of enhancement

the speed of wash-in

the size of thelesion after enhancement

the homogenicity of enhancement

the intensity of enhancement

and the speed of wash-out.Binarymultivariate Logistic regression was used to analyze the malignant risk of each CEUS characteristic in predicting the testicularlesions.ResultsFourteen benign lesions showed no enhancement on CEUS

the remaining 67 lesions showed enhancement

including 31 benign and 36 malignant lesions.The boundary of enhancement

the speed of wash-in

and the size of the lesionafter enhancement were statistically different in benign and malignant testicular lesions（all P<0.05）.There were no statisticallysignificant difference in the homogenicity of enhancement

the intensity of enhancement

and the speed of wash-out. Binarymultivariate Logistic regression analysis screened three CEUS characteristics related to malignant lesions.The relative malignantrisk from high to low is as follows:ill-defined enhanced border

fast wash-in

enlarged size after enhancement（OR=23.188

14.976

10.554

all P=0.000）.ConclusionCEUS is of great value in the differential diagnosis of benign and malignant testicular lesions.