Objective To explore the diagnostic value of contrast-enhanced ultrasonography in analyzing the blood perfusion status of pancreatic cancer model.Methods Forty cases of pancreatic cancer orthotopic xenograft tumor model were divided into control group（n=20） and experimental group（n=20） by random number table method.The experimental group was treated with recombinant human endostatin.The control group was treated with placebo.All animals underwent contrast-enhanced ultrasound before execution.The peak intensity（PI） and the area under the curve（AUC） were measured.Immunohistochemistry was employed to analyze the relative levels of vascular endothelial growth factor（VEGF） and CD34 in pancreatic cancer specimens.Tumor vascular imaging was conducted using the lead oxide-gelatin injection technique to detect the vascular density per unit volume of pancreatic tumor.The relations between PI and micro vascular density as well as the relationships between AUC and micro vascular density were analyzed.Results A significant decrease of PI and AUC were found in experimental group specimens [（32.64±5.15）dB and 523.68±57.06] when compared with the control group[（68.83±7.27）dB and 859.93±114.27]

there were significant difference（both P<0.001）.The microvascular density of control group and experimental group were 32.1±6.43 and 11.7±3.49

the positive expression of CD34 in the experimental group was significantly increased compared with control group

and the difference was statistically significant（t=34.84

P<0.001）.The integrated optical density values of VEGF in control group and experimental group were 284.91±53.86 and 104.64±24.32.The positive expression of VEGF in the experimental group was significantly reduced compared with control group（t=27.13

P<0.001）.The vascular density perunit volume of pancreatic tumor of control group and experimental group were 6.257±1.084 and 1.686±0.421

the difference was statistically significant（t=41.24

P<0.001）.The PI were positively correlated with micro vascular density and vascular density per unit volume in pancreatic cancer tissues（r=0.857

0.896

both P<0.05）.The AUC were positively correlated with micro vessel density and vascular density per unit volume in pancreatic cancer tissues（r=0.762

0.675

both P<0.05）.Conclusion Contrastenhanced ultrasound parameters PI and AUC can accurately evaluate the blood perfusion of pancreatic cancer

and the values of PI and AUC are closely related to the vascular density of pancreatic cancer.