Objective To evaluate the clinical value of different artery peak velocity variation（△Vpeak） for predicting fluid responsiveness in critical patients by meta-analysis.Methods Databases of PubMed

Embase

Medline

Cochrane Library

CBMdisc

Wanfang

CNKI and VIP were retrieved.Two search members collected literatures corresponding to △Vpeak for evaluation of fluid responsiveness in critical patients by beside ultrasound.The related literatures from establishment to May 2019 were screened according to the inclusion and exclusion criteria referencing QUADAS entries

the quality of included literatures was evaluated and the original data included in the literatures were extracted.Stata 15.0 was used to analyze the related literatures

the pooled sensitivity

specificity

positive likelihood ratio

negative likelihood ratio

diagnostic odd ratio of△Vpeak for evaluating fluid responsiveness in critical patients measured by beside ultrasound were calculated

summarized receiver operating characteristic（SROC） curve was drawn and area under curve（AUC） of SROC was calculated.Funnel plot was depicted to assess publication bias in enrolled studies.Results A total of 15 articles were included in the study.The pooled sensitivities were 0.71（95%CI:0.63-0.78）

0.87（95%CI:0.77-0.93）

0.83（95% CI:0.74-0.91） and 0.79（95% CI:0.74-0.83）

the pooled specificities were 0.85（95%CI:0.78-0.90）

0.85（95%CI:0.76-0.91）

0.84（95%CI:0.73-0.91） and 0.85（95%CI:0.81-0.89）

the pooled positive likelihood ratios were 4.7（95%CI:3.1-7.0）

5.8（95%CI:3.5-9.5）

5.1（95%CI:2.9-8.8） and5.3（95%CI:4.1-6.9）

the pooled negative likelihood ratios were 0.34（95%CI:0.26-0.44）

0.16（95%CI:0.09-0.27）

0.21（95%CI:0.13-0.32） and 0.25（95%CI:0.20-0.31）

the diagnostic odd ratios were 13.63（7.57-24.54）

41.04（19.13～88.02）

21.99（10.49～46.11） and 21.87（14.33～31.31）

AUCs of SROC were 0.86（95% CI:0.82～0.88）

0.92（95%CI:0.90～0.94）

0.89（95%CI:0.86-0.91） and 0.89（95%CI:0.86-0.92） for ΔVpeak of brachial

carotid

aortic and their combination in diagnosing fluid responsiveness

respectively.The results of funnel plot demonstrated that there were no publication biases in studies of brachial

carotid

aortic and their combination.Conclusion ΔVpeak can be used to evaluate fluid responsiveness in critical patients

of which ΔVpeak of carotid artery has the highest diagnostic value.