Objective To evaluate the left ventricular function in patients with chronic kidney disease（CKD） by twodimensional speckle tracking strain imaging（2D-STI）

and to explore the correlation between the global longitudinal peak strain of the left ventricle and renal function.Methods A total of 69 CKD patients diagnosed in our hospital were continuously selected

according to glomerular filtration rate（eGFR）

36 patients in mild CKD group（eGFR 30～89 ml/min） and 33 patients in moderate and severe CKD group（eGFR<30 ml/min）.Thirty age and sex matched healthy volunteers were enrolled as control group.The basic clinical data and renal function indexes of all patients were collected

and the indexes of transthoracic echocardiography were measured including interventricular septal end diastolic thickness（IVSTd）

left ventricular end diastolic diameter（LVDd）

left ventricular mass index（LVMI）

left ventricular ejection fraction（LVEF）

left atrial volume index（LA VI）and E/e.The global longitudinal peak strain（GLS） of left ventricle was measured by 2 D-STI.Multiple linear regression was used to analyze the correlation between echocardiography parameters and eGFR.Results Compared with the control group

IVSTd

LAVI and serum creatinine in the mild CKD group were increased

eGFR and GLS were decreased significantly（all P<0.05）.Compared with mild CKD group

systolic blood pressure

total cholesterol

serum creatinine

IVSTd

LVMI

LAVI

E/e were increased

eGFR and GLS were decreased in moderate and severe CKD group（all P<0.05）.Correlation analysis revealed that eGFR were negatively correlated with systolic blood pressure

serum creatinine

IVSTd

LVMI and LAVI

while eGFR was positively correlated with GLS（all P<0.05）.After adjusting the influencing factors by multiple linear regression analysis

GLS and eGFR was still independently and positively correlated（r=0.789

P=0.005）.Conclusion 2D-STI can sensitively reflect the changes of left ventricular function in CKD patients at different stages.With the progression of the disease

the left atrium enlarged and the left ventricular systolic function decreased in patients with chronic renal insufficiency.GLS is independently related to renal function.