Objective To explore the application value of contrast-enhanced ultrasound（CEUS）in percutaneousbiopsy for anterior mediastinum.MethodsA total of 79 patients with anterior mediastinum masses with ultrasound guidedpercutaneous biopsy were enrolled in this study.Before biopsy

39 patients were divided into CEUS group

and 40 patients weredivided into US group.The rate of necrosis display

the number of samples taken and the accuracy of diagnosis in the two groupswere analyzed and compared.ResultsThe rate of necrosis in the CEUS group was 66.67%（26/39）

which was significantlyhigher than that in the US group（22.50%

9/40）

there was significant difference（P<0.05）.According to the pathology

thediagnostic accuracy rate of CEUS group was 94.87%（37/39）

which was significantly higher than that of the US group（77.50%

31/40）

there was significant differences（P<0.05）.In cases of tumors diameter over 5 cm

the diagnostic accuracy rate of CEUSgroup was 97.06%（33/34）

which was significantly higher than that of US group（75.00%

24/32）

there was significantdifferences（P<0.05）.1 patient in CEUS group suffered from subcutaneous hematoma

but no serious complications was found inthe US group.ConclusionCEUS is helpful to identify the necrotic area and alive area in the lesion

thus canbe potentially usedto improve the accuracy and success rate of biopsy

and have fewer adverse reactions.