Objective To systematically and comparatively evaluate the clinical value of contrast-enhanced（）Methods performed on the databases of CNKI

Wanfang

Pub Med

Embase

and Cochrane Library.The retrieval time was from databaseestablishment to December 2018.Relevant literatures on the differential diagnosis of benign and malignant kidney tumors in thesame group examined by CEUS and CECT were collected. Literature screening

data extraction and methodological qualityevaluation are in strict accordance with the inclusion and exclusion criteria.The sensitivity

specificity

positive likelihood ratio

negative likelihood ratio

and diagnostic odds ratio of the two methods for differential diagnosis between malignant renal tumorswas calculated with Stata 14.0 software.Summary receiver operating characteristic（SROC）curve was drawn and the area underthe curve was calculated

and the extent and potential sources of heterogeneity was discussed.ResultsA total of 10 controlledstudies with a total of 1290 lesions were included.The combined sensitivity and specificity of CEUS and CECT in detecting renaltumors were 0.95[95%CI:0.93～0.96]and 0.90（95%CI:0.85～0.93）

0.75（95%CI:0.66～0.83）and 0.72（95%CI:0.63～0.80）

respectively.The diagnostic odds ratios were 59（95%CI:35～100）and 27（95%CI:19 to 40）

respectively

and the areas underthe ROC curve are 0.95（95%CI:0.93～0.97）and 0.89（95%CI:0.86～0.91）

respectively. There was statistically significantdifference in the diagnostic odds ratio between the two methods（P<0.05）.The sensitivity

specificity

and diagnostic odds ratio ofCEUS and CECT for renal tumors≤4 cm in diameter were 0.95（95%CI:0.92～0.97）and 0.87（95%CI:0.82～0.92）

0.76（95%CI:0.65～0.86）and 0.75（95%CI:0.65～0.86）

63（95%CI:34～116）

and 21（95%CI:10～46）.The areas under the SROC curve were0.95（95%CI:0.93～0.97）and 0.90（95%CI:0.87～0.92）.The differences in sensitivity and diagnostic odds ratio were statisticallysignificant（both P<0.05）.ConclusionCEUS has the same high sensitivity and moderate specificity as CECT in the diagnosisof renal tumors.CEUS is more sensitive than CECT in the diagnosis of renal tumors ≤4 cm in diameter.