Objective To explore the application value of combined conventional ultrasound

contrast-enhancedultrasound（CEUS）and tumor markers in the differential diagnosis of benign and malignant peripheral pulmonary lesions.MethodsSeventy-six patients with histopathologically confirmed peripheral pulmonary lesions（30 benign and 46 malignant）were enrolled in this study.Conventional ultrasound

CEUS and tumor marker detection were performed on each patients.Thescores of three methods and the combination of three methods were recorded and compared. Area under receiver operatingcharacteristic（ROC）curve was drawn

the cutoff value of the score

the diagnostic sensitivity and specificity were calculated andcompared.ResultsThe combined score of malignant lesions was significantly higher than that of benign lesions（11.93±2.29 vs.6.90±2.27

P<0.05）.The ROC curve analysis showed that the cutoff value of conventional ultrasound score

CEUS score

tumormarkers score and the combined score were 1.5

6.5

1.5 and 8.5

respectively.The sensitivity and specificity were 89.1%

65.6%

71.7%

93.1% and 76.1%

65.5%

95.7%

76.7%

respectively.The area under the curve and diagnostic sensitivity of the combinedscores were significantly higher than those of any single method score.ConclusionThe combined score of conventional ultrasound

CEUS and tumor marker are of high value in the differential diagnosis of benign and malignant peripheral pulmonary lesions.