In recent years

many studies have confirmed that ultrasound can mediate tumor immunotherapy. High-intensity focused ultrasound（HIFU）can cause tumor fragments to be generated in situ

while destroying tumors.Tumor fragmentscan serve as antigens of the immune system

forming in situ vaccine and inducing the organism to produce a systematic immuneresponse. Microbubble as the carrier

mediated immunity adjuvants targeted to tumor cells and immune cells by ultrasound-targeted microbubble destruction

which not only can enhance the body’s immune response

improve the efficacy of tumorimmunotherapy

but also can reduce the dosage of immunity adjuvants and reduce side effects.This paper reviews the researchprogress in ultrasound mediated tumor immunotherapy and discuss the potential application and possible challenges.