Objective To explore the changes of left ventricular diastolic function in patients with early-onset andlate-onset severe preeclampsia（EOSP

LOSP）by echocardiography.MethodsEighty-three patients of severe preeclampsia（left ventricular ejection fraction ≥50%）were selected.On the basis of gestational week at the onset of disease

these patientswere divided into two groups:PE1 group（48 cases

the EOSP who were diagnosed before 34 gestational weeks）and PE2 group（35 cases

the LOSP who were diagnosed at or after 34 gestational weeks）.Seventy-three healthy pregnancy were selected as thecontrol group

thirty-six of these were selected as the N1 group who were gestational weeks-matched with PE1

other thirty-seven matching the gestational week of the PE2 group were selected as the N2 group. Conventional echocardiography wereperformed and parameters were acquired including:early peak mitralflow velocity（E）

late peak mitral flow velocity（A）

earlymitral annulus diastolic septal wall and lateral wall motion peaks（eS’

eL’）

late diastolic septal and lateral wall motion peaks（aS’

aL’）

and then calculated E/A ratio

eM’

aM’

eM’/aM’ratio and E/eM’ratio.Left atrial maximum volume（LAVmax）wasacquired

and LAVI was obtained by body surface area indexed.The differences between the above parameters in each groupwere analyzed and compared.ResultsCompared with N1 group

E/A

eM’

eM’/aM’were decreased

A

E/eM’

IVRT

LAVI wereincreased in PE1 group（all P<0.05）.Compared with N2 group

E/A

eM’

eM’/aM’were decreased

A

E/eM’

IVRT

LAVI wereincreased in PE2 group（all P<0.05）.Compared with PE1 group

E

E/A

eM’

E/eM’

IVRT

LAVI were decreased

A

aM’

eM’/aM’were increased in PE2 group（all P<0.05）.Compared with N1 group

E

A

eM’

aM’

eM’/aM’were decreased

E/A

E/eM’

LAVI

IVRT were increased in N2 group（all P<0.05）.ConclusionLeft ventricular diastolic function is reduced both in EOSP andLOSP patients.Compared with LOSP

left ventricular diastolic function is inclined to decrease in EOSP.