Objective To investigate the differences of renal stiffness in patients with different pathological types ofprimary nephrotic syndrome by real-time shear wave elastography（SWE）

and to explore its clinical application value.MethodsFifty-one patients with primary nephrotic syndrome as case group and 200 normal subjects as normal control groupwere involved in this research. According to the pathologic results

the case group was further divided into four subgroups:micropathological nephropathygroup（MCN group）

mesangial proliferative glomerulonephritis group（MSPGN group）

focalsegmental glomerulosclerosis group（FSGS group）

and membranous nephropathy group（MN group）.SWE was used to measurethe average（Mean）

maximum（Max）

minimum（Min）

and diffusion（SD）elastic modulus of the bilateral renal parenchyma ineach group

and the results were compared.ResultsThe Mean

Max

and Min of the kidneys in the case group were significantlyhigher than those in the normal control group

and the differences were statistically significant（all P<0.05）.The Mean

Max

andMin of the MSPGN group

the FSGS group

and the MN group were higher than those of the normal control group and the MCN group

and the differences were statistically significan（tall P<0.05）.The other groups were compared in pairs and the differenceswere not statistically significance.Conclusion SWE can primarily evaluate the changes of renal stiffness in patients withprimary nephrotic syndrome with different pathologic types preliminarily by measuring the elastic modulus of bilateral kidneys

which has certain clinical value in providing a certain basis for diagnosis and typing of early diffuse renal disease.