ObjectiveTo explore the clinical application value of real-time shear wave elastography（SWE）in quantitatively evaluate the neonatal brain injury.MethodsA total of 134 neonates who underwent craniocerebral ultrasound were selected.There were 38 premature infants（less than 37 weeks）and 96 cases of full-term infants（more than 37 weeks）.According to the diagnostic criteria of neonatal hypoxic-ischemic encephalopathy（HIE）in neonates

96 full-term infants were divided into full-term normal group（42 cases） and full-term HIE group（54 cases）.According to the ultrasonic diagnostic criteria

38 premature infants were divided into non white matter damage group（20 cases）and white matter damage group（18 cases）.SWE was performed on the parietal lobe

thalamus and cerebellum of the newborn

and the corresponding Young’s modulus value was measured to compare the difference of Young’s modulus value in different parts of the brain damage of the newborn.ResultsThe Young’s modulus of thalamus and cerebellum in full-term normal group were higher than those in full-term HIE group（both P<0.05）.The Young’s modulus of parietal lobe and cerebellum in non while matter damage group were higher than those in white matter damage group（both P<0.05）.ConclusionSWE can quantitatively evaluate the elastic of parietallobe

thalamus and cerebellum

and it can serve as a basis for the more accurate diagnosis of neonatal brain injury.