ObjectiveTo investigate the contrast-enhanced ultrasound characteristics and tumor markers expression in patients with hepatocellular carcinoma（HCC）

and to explore its clincal application value.MethodsA total of 214 patients with HCC confirmed by surgery or puncture pathology who had received contrast-enhanced ultrasonography before surgery were collected.The expression of interleukin-8（IL-8）and alpha fetoprotein（AFP）was observed by immunohistochemical staining.The relationship between the parameters of contrast-enhanced ultrasound（onset time

peaking time

peak acceleration time

initiation rate and enhancement rate）and tumor markers was analyzed

as well as the relationship between the expression of IL-8/AFP and HCC.ResultsThe onset time

peaking time and peak acceleration time of the HCC lesions were less than those of background liver tissue around the lesions

and the initiation rate and enhancement rate of HCC were higher than those of background liver tissue around the lesions（all P<0.05）.The positive rate of IL-8 expression was 74.77%（160/214）

and the positive rate of AFP expression was 69.62%（149/214）.There was a significant positive correlation between the two expressions（r=0.252

P=0.003）.The onset time

peaking time and peak acceleration time of IL-8/AFP negative HCC were greater than those of IL-8/AFP positive HCC（all P<0.05）.Initiation rate and enhancement rate of IL-8/AFP positive HCC were greater than those of IL-8/AFP negative HCC（all P<0.05）.ConclusionThe contrast-enhanced ultrasound characteristics of HCC can provide the basis for biological behavior evaluation

clinical pretreatment and prognosis in patients with HCC hepatectomy

which has better clinical application value.