Objective To investigate the predictive value of D-dimer combined with activated partial thromboplastin time(APTT) for slow/no-reflow of percutaneous coronary intervention(PCI) in patients with acute coronary syndrome(ACS). Methods A total of 181 ACS patients undergoing emergency PCI in our department from November 2015 to June 2018 were recruited in this study. Their plasma D-dimer level and APTT were tested before surgery. According to thrombolysis in myocardial infarction(TIMI)

the patients were divided into slow/no-reflow group and normal blood flow group. The correlations of D-dimer level and APTT were analyzed with the incidence of slow/no-reflow. According to the cutoff values of the 2 indicators

the patients were assigned into high-risk group and non-high-risk group

and the incidence of slow/no-reflow was compared between the 2 groups. Results Logistics multivariate regression analysis showed preoperative D-dimer(OR=2.801

95% CI=1.399～5.610

P=0.004) was positively

and APTT(OR=0.881

95%CI=0.810～0.959

P=0.003) was negatively correlated with slow/no-reflow phenomenon. According to ROC curve

D-dimer AUC=0.612(95% CI=0.537～0.683

P=0.036)

APTT AUC=0.653(95% CI=0.579～0.722

P=0.004)

and AUC increased to 0.697(95% CI=0.624～0.763

P<0.001) when D-dimer was combined with APTT index. According to the cutoff values of D-dimer and APTT

the incidence of slow/no-reflow in high-risk and non-high-risk groups was 36.17% and 14.92%

respectively(P=0.002). Conclusion Higher preoperative D-dimer indicates higher incidence of slow/no-reflow in ACS patients after emergency PCI

while preoperative APTT is negatively correlated with the incidence. So combined detection of the 2 indicators helps predict the occurrence of slow/no-reflow in the patients.