Objective To analyze the clinical features of patients with pseudoretinitis pigmentosa(PRP). Methods We performed a retrospective case analysis among 26 patients with PRP admitted in our department between December

2014 and October

2018

with 30 age-matched patients with RP as the controls. The etiology

disease course

best corrected visual acuity(BCVA)

fundus and full-field flash electroretinogram(FERG) changes were compared between the patients with RP and those with PRP. Results Of the 26 patients with PRP(including 12 male and 14 female patients aged from 26 to 56 years)

22(84.6%) had unilateral PRP and 4(15.4%) had bilateral PRP

and the disease course ranged from 6 months to 5 years. The BCVA of these patients ranged from no light perception to 1.2

and none of the patients complained of night blindness. The 30 control patients with RP included 13 male and 17 female patients with a mean disease duration of 27 years. The primary causes of PRP included uveitis(40.0%)

retinal detachment(36.7%)

ocular trauma(16.7%)

and other factors(6.6%). The patients with RP and PRP had significantly different disease durations and BCVA(P<0.05). The patients with PRP typically manifested a bilateral asymmetry of the fundus

with obvious differences in retinal color

pigment distribution and visual disc color change from patients with RP. FERG of the patients with PRP revealed synchronously decreased amplitudes of the waveforms in the bilateral eyes with obvious eye asymmetry

and the reduction of FERG amplitude was not consistent with the changes in the fundus of the affected eyes. Conclusion The causes of PRP are diverse

and the disease course is often short without night blindness. The changes in the fundus and FERG are the main indicators for differential diagnosis between PRP and RP.