OBJECTIVE: To probe into the characteristics and regularity of adverse drug reactions（ADR） induced by tigecycline

so as to provide reference for clinical rational medication. METHODS: Case reports of ADR induced by tigecycline published from Jan. 2005 to Aug. 2022 were retrieved from CNKI

VIP

Wanfang Data

PubMed

Web of Sciene and Embase. RESULTS: Totally 91 studies related to ADR induced by tigecycline were enrolled

including 108 patients

including 68 males

37 females and 3 unknown gender; patients were mainly aged ≥60 years（61 cases

56.48%）; patients’ primary diseases were mainly pulmonary infection and abdominal infection. The onset time of ADR induced by tigecycline ranged from 10 min after administration to 2.5 months after administration

with most ADR occurred within 7 d after administration（72 cases

66.67%）. ADR induced by tigecycline had involved multiple organs and（or） systems

totally 219 case-times

with digestive system damage（105 case-times

47.95%） being the most common

followed by hematologic system damage（77 case-times

35.16%）. Most patients who developed ADR were improved in symptoms within 1 week after drug withdrawal or receiving symptomatic treatment（68 cases

62.96%）. CONCLUSIONS: ADR induced by tigecycline can involve multiple organs and/or systems

with diverse clinical manifestations

the awareness and monitoring of ADR induced by tigecycline should be strengthened during medication to reduce or avoid the occurrence of ADR

and to ensure safe medication for patients.