OBJECTIVE: To investigate the changes of drug usage in fever clinics of the hospital from Jan. 2019 to Jun. 2022

and to perform objective evaluation on the application situation and trend of common drugs

so as to provide reference for clinical rational medication. METHODS: Data related to commonly used drugs and patient prescriptions in fever clinics of the hospital from Jan. 2019 to Jun. 2022 were retrospectively collected by using the hospital information system

which was analyzed in terms of annual sales amount

annual consumption sum

defined daily dose system（DDDs） and drug combination. RESULTS: Among the drugs used in fever clinics of the hospital from Jan. 2019 to Jun. 2022

the dosage of oral western medicine was higher for Loxoprofen sodium tablets

Levofloxacin tablets and Acetaminophen sustained release tablets

the dosage of oral Chinese patent medicine was higher for Lanqin oral liquid

Jinhua Qinggan granules and Suhuang Zhike capsules; as for injections

the dosage of ceftriaxone for injection the most

and the top three DDDs of western medicine in drug combination with ceftriaxone for injection was much more than the top three DDDs of Chinese patent medicine in drug combination. Among the patients who used ceftriaxone for injection at different ages

the proportion of combined use of ceftriaxone for injection and top 3 western drugs ranked by DDDs gradually increased with the increase of age in 2020 and 2021; from Jan. to Jun. 2022

among the patients aged 60 to <75 who used ceftriaxone for injection

the combination of ceftriaxone for injection and top 3 western drugs ranked by DDDs accounted for the highest proportion. Among the patients who used ceftriaxone for injection at different ages

the proportion of the combination of ceftriaxone for injection and top 3 Chinese patent medicine ranked by DDDs was the highest among the patients <45 years old; with the increase of age

the proportion of the above combined drugs gradually decreased. CONCLUSIONS: The combined application of ceftriaxone for injection with western medicine in department of fever clinic in this hospital is basically reasonable

which is in line with the medication principles of safe

effective and economical efficiency. However

the combined application of ceftriaxone for injection with Chinese patent medicine was unsatisfactory

and it is suggested that clinicians should reasonably combine drugs in the process of treatment to ensure medication safety for patients.