OBJECTIVE: To investigate the application of statins in patients with primary nephrotic syndrome in this hospital

and to probe into the possible drug interactions between various types of statins and cyclosporine

so as to provide reference for rational clinical drug selection. METHODS: The application of statins in patients diagnosed with primary nephrotic syndrome in outpatient department in this hospital from Jan. to Jun. 2022 was retrospectively analyzed; the categories of statins used and their possible drug interactions with cyclosporine were compared and analyzed by using the Lexicomp drug interaction database and dispensatory. RESULTS: From Jan. to Jun. 2022

the main statins used by patients with primary nephrotic syndrome in this hospital included pravastatin

fluvastatin

simvastatin

atorvastatin and rosuvastatin; among them

simvastatin and rosuvastatin were definitely prohibited in combination with cyclosporine in the “contraindications” of the dispensatory. In the Lexicomp database

the drugs with D-class interactions with cyclosporine were pravastatin

fluvastatin and resulvastatin; the drugs with X-class interaction with cyclosporine were simvastatin and atorvastatin. CONCLUSIONS: In the treatment of primary nephrotic syndrome

there are interactions between cyclosporine and statins

and the literature reports do not fully agree with the dispensatory; physicians need to take a comprehensive consideration when making decisions

choosing pravastatin and fluvastatin may be more desirable.