OBJECTIVE: To probe into the effect of low-dose aspirin combined with labetalol and nifedipine on the efficacy in the treatment of pre-eclampsia. METHODS: Totally 254 patients with pre-eclampsia admitted into Huai’an Maternal and Child Health Hospital from Feb. 2021 to Dec. 2021 were prospectively selected and divided into control group and observation group by random number table method

with 127 patients in each group. The observation group was given Labetalol hydrochloride tablets combined with low-dose aspirin tablets

while the control group was given Nifedipine sustained-release tablets combined with low-dose aspirin tablets. The therapeutic effects

serum cystatin C（CysC）

hemodynamic indexes（blood viscosity

hematocrit value

cardiac index）

adverse pregnancy outcomes（intrauterine distress

neonatal asphyxia

uterine inertia

postpartum hemorrhage

cesarean section

premature infants）

adverse drug reactions（nausea

vomiting

myasthenia

abdominal pain） were observed and compared between two groups before and after treatment. To compare and analyze the application value of aspirin combined with labetalol or nifedipine in the treatment of pre-eclampsia. RESULTS: Compared with the control group（88.98%

113/127）

the total effective rate of the observation group（96.85%

123/127） was significantly higher

with statistically significant difference（P<0.05）. After treatment

the CysC level of the observation group lower than that of the control group

with statistically significant difference（P<0.05）. After treatment

the blood viscosity

hematocrit value and cardiac index of both groups had been improved than those before treatment; the blood viscosity and hematocrit value were lower

and the cardiac index was higher in the observation group than the control group

with statistically significant differences（P<0.05）. Compared with the control group

the incidence of adverse pregnancy outcomes of the observation group（17.32%

22/127） was lower than that of the control group（28.35%

36/127）

the incidence of adverse drug reactions of the observation group（2.36%

3/127） was lower than that of the control group（11.02%

14/127）

with statistically significant differences（P<0.05）. CONCLUSIONS: Compared with low-dose aspirin combined with nifedipine

low-dose aspirin combined with labetalol has better efficacy in the treatment of pre-eclampsia

with more significant improvements in renal function and hemodynamics and a lower probability of adverse pregnancy outcomes in patients

without increased adverse drug reactions.