OBJECTIVE: To investigate the research hotspots of monoclonal antibody drugs at home and abroad

and to analyze possible research trends. METHODS: Using the publicly available literature of monoclonal antibody drug research on CNKI and PubMed as basic data（retrieval time: Jan. 1982 to Jan. 2022）

the two document databases were analyzed by using the CiteSpace tool

so as to derive the hotspots and differences of domestic and foreign research. RESULTS: The knowledge map analysis of literature in the two databases showed that breast cancer

antibody-conjugates drugs

clinical trials and targeted therapy are the hotspots of domestic and foreign literature research. CONCLUSIONS: The literature study of CiteSpace suggests that the research of monoclonal antibody drugs is in a period of substantial enhancement

which shows unique advantages and prospects in the fields of oncology

autoimmunity

metabolism and other diseases; China ranks 4th in the world in terms of the number of publications related to monoclonal antibody drug research

and occupies an important position in this research.